You can also select individual cases for download:
Download Selected Files to Your Local Machine:
About PEDIA-BRAIN:
Advancements in scalable and reliable single cell sequencing technologies have significantly enhanced our understanding of the human brain's diversity in terms of gene expression and chromatin accessibility. Numerous research groups have mapped the cellular diversity of the fetal brain with unprecedented detail. However, most studies on the transcriptional and chromatin signatures of the developing human brain have primarily concentrated on the telencephalon or limited developmental timeframes.
The PEDIA-BRAIN (Pediatric Encyclopedia of Development from Infancy to Adulthood - Brain Regions and Associated Integrative Neuroscience) is a public resource encompassing the complete spectrum of human brain development. It incorporates droplet-based single nuclei RNA sequencing and open chromatin profiling (snRNA-seq + snATAC-seq) of normal tissues corresponding to critical stages of postnatal development including infant and toddler (0-2 years), child (4-8 years), adolescent (13-14 years), and early adulthood, at the completion of myelination (31-33 years).
The PEDIA-BRAIN is divided into subsections according to brain region. Currently, only the pons region is available.
Additional Links to:
Steve and Cindy Rasmussen Institute for Genomic Medicine Nationwide Children's HospitalAcknowledgements:
All postnatal normal human pons samples were obtained from the NIH NeuroBioBank.
All sequencing was performed in the Nationwide Children’s Hospital Institute for Genomic Medicine Genomic Sequencing Services Core.
Funding was provided by a generous gift from Community Choice Financial, Inc. to Nationwide Children’s Hospital Institute for Genomic Medicine.